What is Modalert? Modalert is a prescription central nervous system stimulant that helps people stay awake, enhance concentration, and combat fatigue. It is commonly used to treat narcolepsy and shift work sleep disorder but doctors may also prescribe it off-label for many reasons, such as to treat ADHD, for airline pilots, or to treat excessive fatigue associated with medical conditions like cancer or multiple sclerosis (MS). Researchers aren’t exactly sure how Modalert works, but they believe it stimulates the production of monoamines (a class of neurotransmitters), which includes dopamine, noradrenaline, and serotonin. Although Modalert 200 is a highly effective prescription medication, it has the same effect on dopamine centers of the brain as cocaine, methamphetamine, and amphetamines do.1 Like other stimulants, it also causes psychoactive and euphoric effects, which influence a person’s moods, thoughts, emotions, and perceptions. Not surprisingly, due to its ability to stimula